test for leaky gut and sibo img gallery2 test for sibo leaky gut tmao product

4.8/5 Rated

Test for SIBO, Leaky Gut & TMAO

The world’s first single-sample urine test that detects both SIBO, leaky gut and TMAO. Our unique patent pending test identify three primary yet hidden root causes of common health issues-providing personalized guidance based on your specific results.

Get Tested Today

€165

Sold over 258 times last week

Pay safely using these payment methods, powered by

Benefits

Fast & reliable gut health insights

Detects SIBO, leaky gut & TMAO in one test

Personalized recommendations included

Reduces uncertainty & guesswork

Avoids unnecessary treatments/diets

Valuable even with negative results

Single urine sample (no breath test)

High sensitivity detection

Covers key hidden gut issues

Advanced biomarker analysis

This test uses high-sensitivity mass spectrometry to provide a comprehensive view of your gut health from a single urine sample. It enables accurate detection of key biomarkers linked to SIBO, leaky gut, and TMAO-three often overlooked drivers of digestive and metabolic issues.

How the test works

The analysis is based on well-established scientific principles:

  • Curcumin metabolism
    Curcumin is metabolized by gut bacteria into water-soluble compounds that are excreted in urine. These metabolites provide insight into bacterial activity in the small intestine, helping identify SIBO.
  • Lactulose absorption
    Lactulose (not to be confused with lactose) is a synthetic sugar that normally cannot pass through a healthy intestinal barrier. If detected in urine, it indicates increased intestinal permeability-commonly known as leaky gut.
  • TMAO (Trimethylamine N-oxide)
    TMAO is produced when gut bacteria metabolize certain nutrients. Elevated levels may reflect bacterial overgrowth in the small intestine and are associated with low-grade inflammation and long-term cardiometabolic and immune health risks.
What this tells you

By analyzing these biomarkers together, the test provides a clear and clinically relevant assessment of:

  • Small intestinal bacterial overgrowth (SIBO)
  • Intestinal permeability (leaky gut)
  • Bacteria associated with TMAO production

All of this is achieved through a single, non-invasive urine sample-making the process simple, convenient, and reliable.

SIBO, Leaky Gut and TMAO - Hidden Drivers of Poor Health

A growing body of research points to gut imbalance – particularly Small Intestinal Bacterial Overgrowth (SIBO) and increased intestinal permeability (leaky gut) – as underlying contributors to a surprisingly wide range of health challenges. If you’ve been struggling with symptoms that seem unrelated or difficult to explain, your gut health may be at the root of it.

These symptoms can include digestive issues such as IBS and bloating, chronic low-grade inflammation, persistent fatigue and low energy, brain fog and difficulty concentrating, frequent headaches and disrupted sleep, skin conditions such as eczema, food sensitivities, mood imbalances, metabolic concerns, and chronic pain.

Why Early Detection Matters

SIBO and leaky gut often go undetected for years. Research suggests a significant portion of the population may have SIBO without knowing it – and increased intestinal permeability has been associated with several serious chronic conditions, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s, neurological and autoimmune conditions such as Multiple Sclerosis, and metabolic conditions including Type 2 diabetes. While these associations do not imply causation, they underscore just how central gut health is to overall physiology. Identifying imbalances early gives you the opportunity to take proactive steps before symptoms progress..

The Role of TMAO

TMAO (trimethylamine N-oxide) is a compound produced when gut bacteria metabolise certain nutrients. Elevated TMAO levels may be a sign of microbiome imbalance – particularly in the small intestine – and have been associated in research with low-grade inflammation, cardiometabolic risk factors, blood sugar regulation challenges, and immune system imbalance.

Is This Test Right for You?

This test is designed for people who are tired of managing symptoms without answers. It may be especially relevant if you experience ongoing digestive or unexplained symptoms, want to uncover potential root causes rather than just treat what’s on the surface, are interested in preventive and proactive health insights, or want a comprehensive, non-invasive way to assess your gut health.

 

Take control of your gut health – identify hidden imbalances and take the first step toward feeling better.

One simple urine sample is all it takes. No invasive procedures, no clinic visits – just a straightforward at-home test that provides insights into three key markers of gut health: SIBO, leaky gut, and TMAO.

Testing for SIBO (Small Intestinal Bacterial Overgrowth)

The test uses curcumin, a natural compound that the body’s own cells cannot break down – but gut bacteria can. If bacteria are present in the small intestine, they convert curcumin into specific metabolites, including hexahydrocurcumin (HHC). These metabolites are absorbed into the bloodstream and excreted in urine within approximately 90 minutes. Using high-sensitivity mass spectrometry, the test accurately detects these metabolites – revealing the level of bacterial activity in your small intestine.

Testing for Leaky Gut (Intestinal Permeability)

The test also measures lactulose, a synthetic sugar that normally passes through the small intestine with very little absorption. If elevated levels of lactulose appear in the urine around 90 minutes after intake, this indicates that the intestinal lining has become more permeable than it should be – a condition commonly known as leaky gut.

Measuring TMAO Levels

TMAO (trimethylamine N-oxide) is produced when gut bacteria metabolise certain nutrients. Elevated TMAO levels may signal an imbalance in the gut microbiome, particularly in the small intestine, and have been associated in research with low-grade inflammation and long-term cardiometabolic, blood sugar, and immune health factors.

What Happens After Your Test?

Your results come with personalised, holistic recommendations tailored to your specific markers. These include guidance on how to rebalance your gut microbiome, how to reduce stress on the small intestine, and practical dietary and lifestyle strategies for long-term health.

 

While SIBO and leaky gut are not classified as diseases, they may contribute to a wide range of health issues. Understanding what’s happening in your gut is the first step toward addressing it.

 

Take the test today – and take a proactive step toward better gut health, improved well-being, and healthy aging.

The Gutfeeling Labs test is a health and lifestyle assessment designed to provide meaningful insights into gut function and overall well-being. It is not intended to diagnose, treat, or replace medical care — but to give you reliable, science-backed information that supports your health decisions.

A Rigorous Scientific Approach

The test is built on advanced analytical technology using high-sensitivity mass spectrometry — the same class of technology used in leading research laboratories. This enables precise, reproducible detection of three key biomarkers from a single urine sample: bacterial activity in the small intestine, intestinal permeability, and microbial metabolites such as TMAO.

 

The methodology is grounded in established scientific principles and is designed to deliver consistent, trustworthy results.

Working Toward Accreditation

Gutfeeling Labs is currently preparing an application for accreditation under ISO/IEC 17025 — an internationally recognised standard for testing and calibration laboratories. This process encompasses the validation of analytical methods, robust quality control procedures, full documentation and traceability, and a commitment to continuous improvement of laboratory performance.

Our Commitment to Transparency

We hold ourselves to a high standard — not just analytically, but in how we communicate. That means presenting your results clearly and honestly, developing our methods in line with the latest research and regulatory guidance, and maintaining scientific integrity at every step.

 

Our goal is straightforward: to give you insights you can trust, so you can make informed decisions about your health and well-being.

Bundle & Save 20% On Your Entire Order

3-Months Follow Up-Test

First test ships immediately

  • Second test delivered after 3 months
  • Track Before & After progress over time
Add
Additional Partner Pack

Partner Gut Test Pack

A comprehensive SIBO, Leaky Gut, and TMAO kit to test your partner for overgrowth and permeability.

EUR 132
EUR 165
Add
Chronic fatigue and low energy
Brain fog and difficulty concentrating
Anxiety and depression
Mood swings and low mood
Skin issues (acne, eczema, rosacea, psoriasis)
Autoimmune conditions
Hormonal imbalances
Sleep disturbances and insomnia
Bloating and digestive discomfort
Gas and abdominal distension
Type 2 diabetes
Cardiovascular risk factors
Fatty liver disease
Insulin resistance
Fibromyalgia
Weight gain or difficulty losing weight
Food sensitivities and allergies
Food intolerances
Joint and muscle pain
Chronic inflammation
Weakened immune system
Diarrhea or constipation
Headaches and migraines
Sugar cravings
Irritable Bowel Syndrome (IBS)
Parkinson's disease risk
Alzheimer's disease risk
Celiac disease complications
Crohn's disease

Is Your Gut Behind These Health Issues? Get Tested

Why Test Your Gut
with Us?

Find The Root Cause

Find The Root Cause

Uncover hidden gut imbalances behind bloating, fatigue, brain fog, and food reactions with data-backed insights.

One Test. Multiple Insights.

Our patent-pending urine test detects leaky gut and bacterial overgrowth in the small intestine ( SIBO ) – two common causes of health issues.

Most Reliable Gut Test

This advanced test analyzes lactulose and bacterial metabolites via high-sensitivity mass spectrometry to evaluate intestinal permeability and identify SIBO

Results-Based Guidance

If your results exceed reference levels, you’ll receive clear one-on-one guidance to rebalance your gut and support long-term health through practical lifestyle changes.

70%
of the immune system lives in the gut. It influences health, mood, sleep, the aging process & more
95%
Said feel lighter after advise based on analysis results.
*Feedback from customers after personalised recommendations based on their test.
90%
Experienced more regular 
bowel movements
*Results from a 14-day study of 88 healthy Gut Feeling members.
85%
Reported feeling less 
fatigued during the day
*Results from an 8-week study of 33 healthy participants.
80%
Noticed improvements in skin and overall well-being
Following advice and recommendations based on your gut test

Certification in progress meet global standards

Tested using High-sensitivity mass spectrometry

100% Data Security & Privacy

Recommendations based on the individual test results

SIBO doesn't stay in your gut.
It spreads its reach.

A 2024 study in Biomedicines mapped SIBO's links to 12 disease groups across the
entire body. Explore each one below.

Group 1

Gastrointestinal Disorders

51.7%

of IBS patients also test positive for SIBO — the most well-documented group

SIBO and gut disorders share a bidirectional relationship — each worsening the other. In Crohn’s disease, SIBO prevalence reaches up to 88%. Rifaximin therapy that eradicates SIBO has been shown to significantly reduce IBS and IBD symptoms.

Linked conditions
  • Irritable Bowel Syndrome (IBS)
  • Crohn's Disease
  • Ulcerative Colitis
  • Celiac Disease
  • Non-Alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  • Pancreatitis
Group 2

Autoimmune Disease

10×

higher SIBO prevalence in systemic sclerosis patients versus healthy controls

Systemic sclerosis (scleroderma) impairs intestinal motility and delays gut transit — creating ideal conditions for bacterial overgrowth. SIBO affects nearly half of all SSc patients. Fecal calprotectin ≥275 µg/g is a reliable screening marker.

Linked conditions
  • Systemic Sclerosis (Scleroderma)
Group 3

Cardiovascular Diseases

2.1×

association between SIBO and subclinical atheromatous plaques (2022 clinical study)

Reduced cardiac output causes intestinal ischemia, allowing bacteria to enter the bloodstream and trigger inflammation. SIBO is also linked to vitamin K2 deficiency — a key driver of atherosclerotic plaque formation and cardiovascular risk.

Linked conditions
  • Heart Failure
  • Deep Vein Thrombosis
  • Coronary Artery Disease
  • Subclinical Atherosclerosis
Group 4

Metabolic Diseases

78.9%

of hyperlipidemia patients tested positive for SIBO in clinical studies

SIBO is significantly more prevalent in both type 1 and type 2 diabetes, worsening glycemic control. Obesity patients face 2–3× higher SIBO risk. SIBO can trigger hyperlipidemia through disruption of enterohepatic bile acid circulation.

Linked conditions
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Gestational Diabetes
  • Hyperlipidemia
  • Obesity
Group 5

Endocrine Disorders

50%+

of hypothyroidism patients are also found to have SIBO

Hypothyroidism slows intestinal motility, creating ideal conditions for bacterial overgrowth. Bacterial antigens may trigger Hashimoto’s and Graves’ disease via immune dysregulation. Levothyroxine use is a key independent predictor of SIBO development.

Linked conditions
  • Hyperthyroidism
  • Hashimoto's Disease
  • Graves-Basedow Disease
Group 6

Nephrological Disorders

33%

SIBO incidence confirmed in chronic kidney disease compared to healthy controls

Renal failure disrupts gut microbiome balance, promoting bacterial overgrowth. Uremic toxins produced by intestinal bacteria impair kidney tubule function. Increased gut permeability from SIBO allows toxins direct access to the bloodstream and kidneys.

Linked conditions
  • Chronic Kidney Injury
  • Acute Kidney Injury
  • IgA Nephropathy
Group 7

Dermatological Diseases

13×

more likely to have SIBO if you have rosacea — and treating SIBO cleared skin in 71% of cases

SIBO increases gut permeability, allowing pro-inflammatory cytokines to reach the skin via the gut–skin axis. In one landmark study, SIBO eradication led to complete rosacea clearance — sustained for 9 months or more after treatment.

Linked conditions
  • Acne Rosacea
  • Psoriasis
Group 8

Neurological Diseases

~50%

of both Alzheimer’s and Parkinson’s patients test positive for SIBO

Via the gut–brain axis, SIBO produces toxic metabolites that reach the brain, triggering neuroinflammation. In Parkinson’s, SIBO impairs absorption of levodopa — the core treatment drug — and may independently worsen motor function.

Linked conditions
  • Alzheimer's Disease
  • Parkinson's Disease
  • Multiple Sclerosis
Group 9

Developmental Disorders

31%

of autistic children test positive for SIBO — and SIBO worsens autism symptom scores

Children with autism and SIBO show significantly worse developmental scores than SIBO-negative autistic children. Treating SIBO — or improving gut flora through diet — has shown promise in alleviating gastrointestinal symptoms in ASD.

Linked conditions
  • Autism Spectrum Disorder (ASD)
Group 10

Mental Disorders

↓34%

SIBO disrupts tryptophan metabolism — directly reducing serotonin (the ”happiness hormone”) availability

SIBO patients show higher neuroticism, elevated anxiety, and lower extroversion than healthy controls. Rifaximin treatment improved mood disorders alongside gut symptoms in clinical trials, highlighting the direct gut–brain connection.

Linked conditions
  • Depression
  • Anxiety
  • Chronic Stress
Group 11

Genetic Diseases

>50%

SIBO prevalence in cystic fibrosis patients due to CFTR gene mutation effects on gut motility

In cystic fibrosis, a CFTR gene mutation causes abnormal gut mucus, reducing motility and enabling overgrowth. In Familial Mediterranean Fever, SIBO reduces colchicine absorption, making the disease harder to manage and increasing flare severity.

Linked conditions
  • Cystic Fibrosis
  • Familial Mediterranean Fever
Group 12

Gastrointestinal Cancers

↑2×

TLR2 & TLR4 immune receptor expression in SIBO-positive cancer patients — may actively promote progression

Post-operative colorectal and gastric cancer patients are significantly more likely to develop SIBO. In hepatocellular carcinoma, elevated TLR2 and TLR4 expression in SIBO-positive patients suggests SIBO may drive tumour development rather than merely co-exist with it.

Linked conditions
  • Colorectal Cancer
  • Pancreatic Cancer
  • Hepatocellular Carcinoma
  • Cholangiocarcinoma
  • Esophagogastric Cancer
  • Gastric Cancer
SV-Success Stories

SV-Trusted Journeys to
Better Gut Health

Google
SV-Google Reviews

4.8

172 reviews

Easy testing process
at-home

01

Register your kit

Collect a urine sample 1.5 hours after drinking the solution and ship your sample to our laboratory

02

Perform your test

The test starts with a drink containing lactulose, glucose, and curcumin, with dosage adjusted by body weight if needed.

03

Collect & ship your sample

Collect a urine sample 1.5 hours after drinking the solution and ship your sample to our laboratory

04

Results & Tailored Guidance

Receive results within 2–10 days, along with personalized gut health insights and actionable recommendations.

A Complete Look Into Your Gut

Discover how your unique microbiome affects your health. Get an expert analysis of key findings plus a personalized coaching session to help you manage and heal microbiome-related conditions from within.

Metabolite Values

How the Science Works

Our test is based on three well-established principles. Measuring these bio-markers together provides a reliable view of intestinal permeability and bacterial presence in the small intestine.

<10ng/ml

Hexahydrocurcumin

A balanced gut microbiome supports digestion, energy, mood, immunity, and brain health.

<110µg/ml

Lactulose

A healthy gut barrier supports immune balance and protects long-term brain health.

<6.2µM

Trimethylamine N-Oxide

A healthy level associated with a lower risk of major cardiovascular events like heart attack and stroke

What make us better

How Our Test Compares

Parameter Gutfeeling Labs Endoscopy Breath Test Stool Test
Technology Mass Spectrometry Bacterial Growth Biochemical Analysis Microscopy, DNA Analysis
Non-Invasive
At-Home Collection
Root Cause Analysis
Number of Samples 1
Expert Consultation 10 mins (Paid) Extra Cost
Cost €165 €900-€1200 €250–€600 €200–€500
Of continuous Research
0 Years
Of microbiome Data
0 TB
Samples Analyzed
0 K+
Microbes Detected
0 K

The
Science of
TMAO

TMAO is produced when gut bacteria break down foods like red meat and eggs and it may be quietly increasing your risk of heart disease.Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

0 x

Higher all-cause mortality risk with elevated TMAO levels

0 %

of heart disease risk goes undetected by standard cholesterol panels

Silent Cardiac Risk

Elevated TMAO promotes atherosclerosis, clot formation, and thrombosis – increasing the risk of heart attack and stroke.

Why Testing TMAO Changes Everything?

  • TMAO is modifiable, unlike genetic risk factors.
  • Reflects active gut microbiome function.
  • A simple blood test can reveal hidden cardiovascular risk missed by standard cholesterol tests.
  • Offers insight into the gut–heart connection.

Beyond Cholesterol

TMAO disrupts reverse cholesterol transport, causing lipid buildup in vessel walls even when LDL appears normal.

The Gut–Kidney Link

Elevated TMAO is associated with kidney disease, cognitive decline, & widespread inflammation.

Gut Bacteria Make It

Gut microbes break down choline and L-carnitine from red meat, eggs and fish, producing TMA, which the liver converts into TMAO.

Driven by science

Meet the brilliant minds behind Gutfeeling Labs

Our advisory board includes Lund University experts with 5,400+ citations, and patented research.

Quote

At GutFeeling Labs, we set out to change how gut health is understood. Too many people struggle with persistent symptoms without clear answers. By combining advanced analytical science with practical insights, our goal is to replace uncertainty with clarity—and empower better health decisions.

Dr. Hans Fischer

CMO of Gutfeeling Labs & Associate Professor Of Immunology & Microbiology at Lund University

Quote

I’ve seen firsthand how frustrating it can be to search for answers to ongoing gut issues. GutFeeling Labs was created to bridge the gap between complex science and real-life health decisions—offering clarity, accuracy, and guidance you can rely on.

Dr. Walter Fischer

CEO of Gutfeeling Labs & NeuroSurgeon & Associate Professor Of Neuroscience at Lund University

SV-Introducing
GutClear®

SV-Clinically designed to rebalance your Gut

leaf

SV-Plant-based, science-backed formula

SV-Supports smooth digestion and gut movement

SV-Supports gut reset before changing diet

SV-Reduces gut-driven body discomfort

SV-Targets small-intestine bacterial overgrowth

SV-Gentle on the colon gut microbiome

SV-Sold over 258 times last week

SV-Start Feeling Better
Frequently asked
questions

We’ve got the answers

What does the test for SIBO, Leaky Gut & TMAO tell me?

We analyze the presence of a well-known marker for leaky gut (lactulose) and bacterial metabolites that accumulate in the bladder during the 90 minutes it takes for the fiber solution to pass through your small intestine. Elevated levels of lactulose indicate increased intestinal permeability (leaky gut), while the presence of specific bacterial metabolites indicates SIBO.

Because our test detects metabolites from a broad range of gut bacteria, we can more reliably determine if bacteria are present in the small intestine. It only takes one metabolite exceeding the reference range for your condition to be classified as SIBO.

If your test result is positive for leaky gut and/or SIBO, you’ll receive personalized dietary and supplement advice, as well as suggestions for lifestyle changes to support your well-being.

What does the test for SIBO, Leaky Gut & TMAO measure?

The test measures the presence of a well-known marker for leaky gut (lactulose, not to be confused with lactose) and bacterial metabolites that can only be produced by bacteria as the fiber solution passes through the small intestine. The metabolites are detected using a highly advanced mass spectrometry system (Agilent Ultivo).

Why should I test for SIBO, Leaky Gut & TMAO?

A sensitive and bloated stomach, food intolerances, joint and muscle pain, eczema, fatigue, brain fog, low mood, headaches, and sugar cravings may all be caused by leaky gut. One common cause of leaky gut is bacterial overgrowth in the small intestine (SIBO), which can develop due to factors such as chronic stress.

Does what I eat in the days before the test affect the results?

Yes, significantly. Avoid taking lactulose-based laxatives (Lactulose/Duphalac®), Imodium®, Dimor®, Loperamide®, fermented foods, curry, turmeric, and curcumin supplements two days before the test.

Can I take probiotic supplements and still do the test?

No. Since our test analyzes bacterial metabolites from bacteria in the small intestine, taking probiotics or synbiotics could affect the results by introducing additional bacteria.

What makes Gutfeeling Labs’ test unique?

We’ve developed a completely new method for SIBO, Leaky Gut & TMAO. The test is based on mass spectrometry, identifying both a known marker for leaky gut (lactulose) and bacterial metabolites in a single analysis. This approach is unique on the market, as it measures metabolites from a wide range of bacteria (not just gas-producing ones) and uses a urine sample-allowing metabolites to accumulate in the bladder during the 90 minute passage of the fiber solution’s passage through the small intestine. By this, a significantly higher sensitivity for detecting bacteria in the small intestine is accomplished.

Can children and adolescents take the test for SIBO, Leaky Gut & TMAO?

Yes-provided there is no allergy or sensitivity to the ingredients. The fiber solution contains compounds found in everyday foods: glucose, curcumin, and lactulose (the latter also forms when milk is heated). The powder is dissolved in a glass of water and the dosage is adjusted according to weight (e.g., adults drink a full glass, someone around 40 kg drinks half a glass, etc.).

Where are the analyses performed?

All analyses are carried out using commercial systems (Agilent) routinely used for clinical testing at the Division of Occupational and Environmental Medicine, Medicon Village, Lund.

Who owns the test results?

The test data belongs to Gutfeeling Labs. We do not sell your test results, data, personal information, or similar. You can read more about how we comply with GDPR in our Privacy Policy.

How soon will I see results after testing positive for SIBO, Leaky Gut & TMAO?

This varies greatly-from as little as one day to several months. It depends on how long leaky gut and/or SIBO has been present and how much of the small intestine is affected by SIBO. Our experience is that GutClear® speeds up the recovery.

Can I order a test for someone else?

Yes. The analysis is linked to a specific person and account only when the kit is activated. Instructions for this process are included in the kit.

How fast will I receive my test kit?

Orders are usually shipped the following business day. International Delivery via PostNord typically takes 5–10 business days.

How long does the test kit stay valid?

Your test kit can be stored at room temperature for up to 18 months. Once the test is completed, it should be mailed within 3 weeks, ideally as soon as possible. If that’s not possible, we recommend freezing the sample until it can be sent.

Can this test diagnose diseases?

No, this is not a diagnostic test and cannot be used for medical diagnosis. It identifies conditions in the small intestine, but neither SIBO nor  leaky gut nor TMAO are officially recognized medical diagnoses.

Are results affected by pregnancy?

No, pregnancy does not affect the results.

Still Got Questions?