Is Your Gut Behind These Health Issues? Get Tested
Why Test Your Gut with Us?
Find The Root Cause
Uncover hidden gut imbalances behind bloating, fatigue, brain fog, and food reactions with data-backed insights.
One Test. Multiple Insights.
Our patent-pending urine test detects leaky gut and bacterial overgrowth in the small intestine (SIBO) – two common causes of health issues.
Most Reliable Gut Test
This advanced test analyzes lactulose and bacterial metabolites via high-sensitivity mass spectrometry to evaluate intestinal permeability and identify SIBO
Results-Based Guidance
If your results exceed reference levels, you’ll receive clear one-on-one guidance to rebalance your gut and support long-term health through practical lifestyle changes.
Certification in progress meet global standards
Tested using High-sensitivity mass spectrometry
100% Data Security & Privacy
Recommendations based on the individual test results
SIBO doesn't stay in your gut. It spreads its reach.
A 2024 study in Biomedicines mapped SIBO's links to 12 disease groups across the entire body. Explore each one below.
Gastrointestinal Disorders
51.7%
of IBS patients also test positive for SIBO — the most well-documented group
SIBO and gut disorders share a bidirectional relationship — each worsening the other. In Crohn’s disease, SIBO prevalence reaches up to 88%. Rifaximin therapy that eradicates SIBO has been shown to significantly reduce IBS and IBD symptoms.
Linked conditions
- Irritable Bowel Syndrome (IBS)
- Crohn's Disease
- Ulcerative Colitis
- Celiac Disease
- Non-Alcoholic Fatty Liver Disease
- Liver Cirrhosis
- Pancreatitis
Autoimmune Disease
10×
higher SIBO prevalence in systemic sclerosis patients versus healthy controls
Systemic sclerosis (scleroderma) impairs intestinal motility and delays gut transit — creating ideal conditions for bacterial overgrowth. SIBO affects nearly half of all SSc patients. Fecal calprotectin ≥275 µg/g is a reliable screening marker.
Linked conditions
- Systemic Sclerosis (Scleroderma)
Cardiovascular Diseases
2.1×
association between SIBO and subclinical atheromatous plaques (2022 clinical study)
Reduced cardiac output causes intestinal ischemia, allowing bacteria to enter the bloodstream and trigger inflammation. SIBO is also linked to vitamin K2 deficiency — a key driver of atherosclerotic plaque formation and cardiovascular risk.
Linked conditions
- Heart Failure
- Deep Vein Thrombosis
- Coronary Artery Disease
- Subclinical Atherosclerosis
Metabolic Diseases
78.9%
of hyperlipidemia patients tested positive for SIBO in clinical studies
SIBO is significantly more prevalent in both type 1 and type 2 diabetes, worsening glycemic control. Obesity patients face 2–3× higher SIBO risk. SIBO can trigger hyperlipidemia through disruption of enterohepatic bile acid circulation.
Linked conditions
- Type 1 Diabetes
- Type 2 Diabetes
- Gestational Diabetes
- Hyperlipidemia
- Obesity
Endocrine Disorders
50%+
of hypothyroidism patients are also found to have SIBO
Hypothyroidism slows intestinal motility, creating ideal conditions for bacterial overgrowth. Bacterial antigens may trigger Hashimoto’s and Graves’ disease via immune dysregulation. Levothyroxine use is a key independent predictor of SIBO development.
Linked conditions
- Hyperthyroidism
- Hashimoto's Disease
- Graves-Basedow Disease
Nephrological Disorders
33%
SIBO incidence confirmed in chronic kidney disease compared to healthy controls
Renal failure disrupts gut microbiome balance, promoting bacterial overgrowth. Uremic toxins produced by intestinal bacteria impair kidney tubule function. Increased gut permeability from SIBO allows toxins direct access to the bloodstream and kidneys.
Linked conditions
- Chronic Kidney Injury
- Acute Kidney Injury
- IgA Nephropathy
Dermatological Diseases
13×
more likely to have SIBO if you have rosacea — and treating SIBO cleared skin in 71% of cases
SIBO increases gut permeability, allowing pro-inflammatory cytokines to reach the skin via the gut–skin axis. In one landmark study, SIBO eradication led to complete rosacea clearance — sustained for 9 months or more after treatment.
Linked conditions
- Acne Rosacea
- Psoriasis
Neurological Diseases
~50%
of both Alzheimer’s and Parkinson’s patients test positive for SIBO
Via the gut–brain axis, SIBO produces toxic metabolites that reach the brain, triggering neuroinflammation. In Parkinson’s, SIBO impairs absorption of levodopa — the core treatment drug — and may independently worsen motor function.
Linked conditions
- Alzheimer's Disease
- Parkinson's Disease
- Multiple Sclerosis
Developmental Disorders
31%
of autistic children test positive for SIBO — and SIBO worsens autism symptom scores
Children with autism and SIBO show significantly worse developmental scores than SIBO-negative autistic children. Treating SIBO — or improving gut flora through diet — has shown promise in alleviating gastrointestinal symptoms in ASD.
Linked conditions
- Autism Spectrum Disorder (ASD)
Mental Disorders
↓34%
SIBO disrupts tryptophan metabolism — directly reducing serotonin (the “happiness hormone”) availability
SIBO patients show higher neuroticism, elevated anxiety, and lower extroversion than healthy controls. Rifaximin treatment improved mood disorders alongside gut symptoms in clinical trials, highlighting the direct gut–brain connection.
Linked conditions
- Depression
- Anxiety
- Chronic Stress
Genetic Diseases
>50%
SIBO prevalence in cystic fibrosis patients due to CFTR gene mutation effects on gut motility
In cystic fibrosis, a CFTR gene mutation causes abnormal gut mucus, reducing motility and enabling overgrowth. In Familial Mediterranean Fever, SIBO reduces colchicine absorption, making the disease harder to manage and increasing flare severity.
Linked conditions
- Cystic Fibrosis
- Familial Mediterranean Fever
Gastrointestinal Cancers
↑2×
TLR2 & TLR4 immune receptor expression in SIBO-positive cancer patients – may actively promote progression
Post-operative colorectal and gastric cancer patients are significantly more likely to develop SIBO. In hepatocellular carcinoma, elevated TLR2 and TLR4 expression in SIBO-positive patients suggests SIBO may drive tumour development rather than merely co-exist with it.
Linked conditions
- Colorectal Cancer
- Pancreatic Cancer
- Hepatocellular Carcinoma
- Cholangiocarcinoma
- Esophagogastric Cancer
- Gastric Cancer
Over 30,000 Satisfied Customers
A closer look at the test process
01
Activate your test
Register your kit online so we can send your results.
02
Prepare for the test
For 48 hours, avoid the restricted foods, supplements, and products listed in the leaflet.
03
Mix & drink the solution
Empty your bladder, mix Fiber + Lactulose in water for 1 minute, drink it, then drink one more glass of water.
04
Wait 1.5 hours
Set a 90-minute alarm. You may eat after 20 minutes, but avoid coffee or tea.
05
Collect your sample
Urinate into the paper cup and use the pipette to fill the barcode tube halfway.
06
Boil, pack & send
Tighten the cap, boil the tube for 10 minutes, let it cool, seal it in the zip bag, and mail it.
A Complete Look Into Your Gut
Discover how your unique microbiome affects your health. Get an expert analysis of key findings plus a personalized coaching session to help you manage and heal microbiome-related conditions from within.
How the Science Works
Our test is based on three well-established principles. Measuring these bio-markers together provides a reliable view of intestinal permeability and bacterial presence in the small intestine.
Hexahydrocurcumin
A balanced gut microbiome supports digestion, energy, mood, immunity, and brain health.
Lactulose
A healthy gut barrier supports immune balance and protects long-term brain health.
Trimethylamine N-Oxide
A healthy level associated with a lower risk of major cardiovascular events like heart attack and stroke
Imidazole propionate
A healthy level supports insulin sensitivity, balanced blood sugar and long-term metabolic and cardiovascular health.
How Our Test Compares
| Parameter | Gutfeeling Labs | Endoscopy | Breath Test | Stool Test |
|---|---|---|---|---|
| Technology | Mass Spectrometry | Bacterial Growth | Biochemical Analysis | Microscopy, DNA Analysis |
| Non-Invasive | ||||
| At-Home Collection | ||||
| Root Cause Analysis | ||||
| Number of Samples | 1 | |||
| Expert Consultation | 10 mins (Paid) | Extra Cost | ||
| Cost | €165 | €900-€1200 | €250–€600 | €200–€500 |
The
Science of SIBO
SIBO occurs when bacteria migrate from your large intestine into the small intestine, disrupting the gut barrier and triggering widespread symptoms throughout your body.
Leaky Gut
Bacterial overgrowth weakens the intestinal barrier, allowing toxins into your bloodstream, which may lead to widespread health issues
Fiber Triggers Symptoms
Bacteria in the wrong place (small intestine) can ferment fiber, leading to excess gas and symptoms such as bloating and abdominal discomfort.
Gut Controls Immunity
The small intestine normally contains significantly fewer bacteria than the large intestine. It is not adapted to handle large amounts of bacteria, and imbalances may therefore negatively affect both the intestinal barrier and the immune system.
Beyond Bacteria
SIBO may have multiple underlying causes. Factors such as stress, reduced gastric acid, impaired motility, and diet may all contribute.
Invisible Symptoms
Symptoms go beyond bloating, brain fog, skin issues, food intolerances, autoimmunity, anxiety, and weight changes.
The
Science of
TMAO
TMAO is produced when gut bacteria break down foods like red meat and eggs and it may be quietly increasing your risk of heart disease.
Higher all-cause mortality risk with elevated TMAO levels
of heart disease risk goes undetected by standard cholesterol panels
Silent Cardiac Risk
Elevated TMAO promotes atherosclerosis, clot formation, and thrombosis – increasing the risk of heart attack and stroke.
Why Testing TMAO Changes Everything?
- TMAO is modifiable, unlike genetic risk factors.
- Reflects active gut microbiome function.
- A simple urine test can reveal hidden cardiovascular risk missed by standard cholesterol tests.
- Offers insight into the gut–heart connection.
Beyond Cholesterol
TMAO disrupts reverse cholesterol transport, causing lipid buildup in vessel walls even when LDL appears normal.
The Gut–Kidney Link
Gut Bacteria Make It
Gut microbes break down choline and L-carnitine from red meat, eggs and fish, producing TMA, which the liver converts into TMAO.
The Science
of ImP
You already track cholesterol, glucose, and blood pressure. ImP adds a new layer: how your gut microbiome may be shaping your metabolic health. Elevated levels have been linked to insulin resistance, type 2 diabetes, cardiovascular disease, and chronic inflammation – often before symptoms appear.
higher odds of prediabetes with high ImP – a signal that appears before full-blown diabetes
develops
higher 5-year mortality risk in heart disease patients with the highest ImP levels vs. the lowest – independent of traditional cardiovascular risk factors
Gut bacteria produce it
Certain gut microbes convert the amino acid histidine into imidazole propionate. Elevated ImP appears to reflect an unhealthy microbiome rather than simply eating more protein.
Appears before diagnosis
ImP has been found to rise in people with prediabetes, suggesting it could serve as an early warning biomarker before blood sugar becomes severely abnormal.
Beyond diabetes
Elevated ImP has also been linked to heart failure, coronary artery disease, systemic inflammation, blood pressure, and early Alzheimer’s disease biomarkers in recent research cohorts.
Disrupts metabolism
Laboratory studies have shown ImP can impair insulin signaling and reduce the effectiveness of metformin by disrupting key metabolic pathways, making it more than just a passive marker.
Reflects gut health
Two people can have the same glucose or HbA1c but very different gut microbial metabolism. ImP provides insight into one pathway through which the microbiome may influence metabolic health.
Driven by science
Meet the minds behind Gutfeeling Labs
Our advisory board includes Lund University science-based experts with high-level publications and patented research.
At Gutfeeling Labs, we set out to change how gut health is understood. Too many people struggle with persistent issues without clear answers. By combining advanced analytical science with practical insights, our goal is to replace uncertainty with clarity—and empower better health decisions.
Dr. Hans Fischer, PhD
Head of R&D & Co-Founder, Gutfeeling Labs
Assoc. Prof. of Immunology & Microbiology
Lund University
I’ve seen firsthand how frustrating it can be to search for answers to ongoing gut issues. Gutfeeling Labs was created to bridge the gap between complex science and real-life health decisions—offering clarity, accuracy, and guidance you can rely on.
Dr. Walter Fischer, MD PhD
CEO & Founder, Gutfeeling Labs
Assoc. Prof. of Neuroscience
Lund University
Introducing
GutClear®
Designed To Rebalance Your Gut
Plant-based, science-backed formula
Supports smooth digestion and gut movement
Supports gut reset before changing diet
Reduces gut-driven body discomfort
Targets small-intestine bacterial overgrowth
Gentle on the colon gut microbiome
Sold over 258 times last month
Start Feeling Better
Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
This review explains how TMAO is produced (gut bacteria convert dietary choline, carnitine, and betaine into TMA, which the liver enzyme FMO3 oxidizes to TMAO)...
Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes
This retrospective observational study examined 104 T2DM patients from Tianjin Medical University Chu Hsien-I Memorial Hospital (April 2016–August 2018), split into SIBO-positive (56 patients) and...
Association between small intestine bacterial overgrowth and psychiatric disorders
This mini-review synthesizes literature (screened from over 2.6 million initial records down to a focused set of studies, 1992–2023) exploring how SIBO affects tryptophan metabolism...
Elevated lipopolysaccharide binding protein in Alzheimer’s disease patients with APOE3/E3 but not APOE3/E4 genotype
Researchers measured lipopolysaccharide binding protein (LBP), a marker of gut permeability and bacterial endotoxin exposure, in the 1.21–1.25 g/mL density fraction of plasma (enriched in...
Small Intestinal Bacterial Overgrowth (SIBO) and Twelve Groups of Related Diseases—Current State of Knowledge
This is a comprehensive literature review examining the relationship between small intestinal bacterial overgrowth (SIBO)—a condition defined by excessive/altered bacterial colonization of the small intestine—and...
Dr. Hans Fischer, PhD
Head of R&D & Co-Founder, Gutfeeling Labs
Associate Prof. of Immunology & Microbiology
Lund University
THE STORY BEHIND THE LAB
If you’ve ever felt unwell without knowing why, Hans has been there. That’s exactly why he built a test that gives you real answers.
How Hans overcame SIBO
questions
We’ve got the answers
We analyze the presence of a well-known marker for leaky gut (lactulose) and bacterial metabolites that accumulate in the bladder during the 90 minutes it takes for the fiber solution to pass through your small intestine. Elevated levels of lactulose indicate increased intestinal permeability (leaky gut), while the presence of specific bacterial metabolites indicates SIBO.
Because our test detects metabolites from a broad range of gut bacteria, we can more reliably determine if bacteria are present in the small intestine. It only takes one metabolite exceeding the reference range for your condition to be classified as SIBO.
If your test result is positive for leaky gut and/or SIBO, you’ll receive personalized dietary and supplement advice, as well as suggestions for lifestyle changes to support your well-being.
The test measures the presence of a well-known marker for leaky gut (lactulose, not to be confused with lactose) and bacterial metabolites that can only be produced by bacteria as the fiber solution passes through the small intestine. The metabolites are detected using a highly advanced mass spectrometry system (Agilent Ultivo).
A sensitive and bloated stomach, food intolerances, joint and muscle pain, eczema, fatigue, brain fog, low mood, headaches, and sugar cravings may all be caused by leaky gut. One common cause of leaky gut is bacterial overgrowth in the small intestine (SIBO), which can develop due to factors such as chronic stress.
Yes, significantly. Avoid taking lactulose-based laxatives (Lactulose/Duphalac®), fermented foods, curry, turmeric, and curcumin supplements two days before the test. Bulk-forming or osmotic laxatives do not interfere with the analysis.
No. Since our test analyzes bacterial metabolites from bacteria in the small intestine, taking probiotics or synbiotics could affect the results by introducing additional bacteria.
We’ve developed a completely new method for SIBO, Leaky Gut, Cardiovascular & Metabolic Riskfactors. The test is based on mass spectrometry, identifying both a known marker for leaky gut (lactulose) and bacterial metabolites in a single analysis. This approach is unique on the market, as it measures metabolites from a wide range of bacteria (not just gas-producing ones) and uses a urine sample-allowing metabolites to accumulate in the bladder during the 90 minute passage of the fiber solution’s passage through the small intestine. By this, a significantly higher sensitivity for detecting bacteria in the small intestine is accomplished.
Yes-provided there is no allergy or sensitivity to the ingredients. The fiber solution contains compounds found in everyday foods: glucose, curcumin, and lactulose (the latter also forms when milk is heated). The powder is dissolved in a glass of water and the dosage is adjusted according to weight (e.g., adults drink a full glass, someone around 40 kg drinks half a glass, etc.).
All analyses are carried out at our laboratory in Lund, Sweden, using commercial systems (Agilent) routinely used for clinical testing.
The test data belongs to Gutfeeling Labs. We do not sell your test results, data, personal information, or similar. You can read more about how we comply with GDPR in our Privacy Policy.
This varies greatly-from as little as one day to several months. It depends on how long leaky gut and/or SIBO has been present and how much of the small intestine is affected by SIBO. Our experience is that GutClear® speeds up the recovery.
Yes. The analysis is linked to a specific person and account only when the kit is registered (e-mail coupled to the test-kit-ID). Instructions for this process are included in the kit.
Orders are usually shipped the following business day. International Delivery via PostNord typically takes 5–10 business days.
Your test kit can be stored at room temperature for up to 18 months. Once the test is completed, it should be mailed ideally as soon as possible; however the sample is stable in room and outdoor temperature over 3 weeks.
No, this is not a diagnostic test and cannot be used for medical diagnosis. It identifies conditions in the small intestine, but neither SIBO nor leaky gut nor TMAO are officially recognized medical diagnoses in Sweden.
No, pregnancy does not affect the results.
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